CovidSeniorV1, Main, Exploration, bibRecord, 000123

Thrombotic complications and anticoagulation in COVID-19 pneumonia: a New York City hospital experience.

Identifieur interne : 000123 ( Main/Exploration ); précédent : 000122; suivant : 000124

Thrombotic complications and anticoagulation in COVID-19 pneumonia: a New York City hospital experience.

Auteurs : Ahmad Hanif [États-Unis] ; Sumera Khan [États-Unis] ; Nikhitha Mantri [États-Unis] ; Sana Hanif [États-Unis] ; Muhamed Saleh [États-Unis] ; Yamini Alla [États-Unis] ; Siddharth Chinta [États-Unis] ; Nikee Shrestha [États-Unis] ; Wenyan Ji [États-Unis] ; Kristopher Attwood [États-Unis] ; Muhammad Adrish [États-Unis] ; Kevin R. Jain [États-Unis]

Source :

Annals of hematology [ 1432-0584 ] ; 2020.

RBID : pubmed:32808105

Descripteurs français

KwdFr :
- Accident vasculaire cérébral (épidémiologie), Adulte d'âge moyen (MeSH), Anticoagulants (administration et posologie), Anticoagulants (usage thérapeutique), Betacoronavirus (MeSH), Durée du séjour (MeSH), Femelle (MeSH), Hispano-américain (MeSH), Humains (MeSH), Hémorragie (épidémiologie), Hôpitaux communautaires (MeSH), Hôpitaux urbains (MeSH), Infections à coronavirus (complications), Infections à coronavirus (thérapie), Mâle (MeSH), New York (ville) (épidémiologie), Pandémies (MeSH), Pneumopathie virale (complications), Pneumopathie virale (thérapie), Population d'origine africaine (MeSH), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Thromboembolisme veineux (épidémiologie), Thrombose (prévention et contrôle), Thrombose (virologie), Thrombose (épidémiologie), Ventilation artificielle (MeSH), Études rétrospectives (MeSH).
MESH :
- administration et posologie : Anticoagulants.
- prévention et contrôle : Thrombose.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Anticoagulants, Infections à coronavirus, Pneumopathie virale.
- virologie : Thrombose.
- épidémiologie : Accident vasculaire cérébral, Hémorragie, New York (ville), Thromboembolisme veineux, Thrombose.
- Adulte d'âge moyen, Betacoronavirus, Durée du séjour, Femelle, Hispano-américain, Humains, Hôpitaux communautaires, Hôpitaux urbains, Mâle, Pandémies, Population d'origine africaine, Résultat thérapeutique, Sujet âgé, Ventilation artificielle, Études rétrospectives.

English descriptors

KwdEn :
- African Continental Ancestry Group (MeSH), Aged (MeSH), Anticoagulants (administration & dosage), Anticoagulants (therapeutic use), Betacoronavirus (MeSH), Coronavirus Infections (complications), Coronavirus Infections (therapy), Female (MeSH), Hemorrhage (epidemiology), Hispanic Americans (MeSH), Hospitals, Community (MeSH), Hospitals, Urban (MeSH), Humans (MeSH), Length of Stay (MeSH), Male (MeSH), Middle Aged (MeSH), New York City (epidemiology), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (therapy), Respiration, Artificial (MeSH), Retrospective Studies (MeSH), Stroke (epidemiology), Thrombosis (epidemiology), Thrombosis (prevention & control), Thrombosis (virology), Treatment Outcome (MeSH), Venous Thromboembolism (epidemiology).
MESH :
- chemical , administration & dosage : Anticoagulants.
- chemical , therapeutic use : Anticoagulants.
- geographic , epidemiology : New York City.
- complications : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Hemorrhage, Stroke, Thrombosis, Venous Thromboembolism.
- prevention & control : Thrombosis.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- virology : Thrombosis.
- African Continental Ancestry Group, Aged, Betacoronavirus, Female, Hispanic Americans, Hospitals, Community, Hospitals, Urban, Humans, Length of Stay, Male, Middle Aged, Pandemics, Respiration, Artificial, Retrospective Studies, Treatment Outcome.

Abstract

Infection with SARS-CoV-2 (COVID-19) can cause prothrombotic complications. We aim to study the frequency of thrombotic complications and impact of anticoagulation on outcomes in hospitalized patients. We conducted a retrospective chart review of 921 consecutive patients admitted to our hospital with COVID-19. Patients were divided into four groups depending on whether they were on anticoagulation prior to admission, started anticoagulation during the admission, received prophylactic anticoagulation, or did not receive any anticoagulation. At the time of analysis, 325 patients (35.3%) had died, while 544 patients (59%) had been discharged resulting in inpatient mortality of 37.3%. Male sex, age > 65 years, and high D-dimer at admission were associated with higher mortality. Sixteen patients (1.7%) had venous thromboembolism confirmed with imaging, 11 patients had a stroke, and 2 patients developed limb ischemia. Treatment with therapeutic anticoagulation was associated with improved inpatient mortality compared with prophylactic anticoagulation alone (63% vs 86.2%, p < 0.0001) in patients requiring mechanical ventilation. Other outcomes such as rates of liberation from mechanical ventilation and duration of mechanical ventilation were not significantly impacted by the type of anticoagulation.

DOI: 10.1007/s00277-020-04216-x
PubMed: 32808105
PubMed Central: PMC7430929

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000602
to stream Main, to step Curation: 000602

Le document en format XML

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<term>Anticoagulants (therapeutic use)</term>
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<term>Pneumopathie virale</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Betacoronavirus</term>
<term>Durée du séjour</term>
<term>Femelle</term>
<term>Hispano-américain</term>
<term>Humains</term>
<term>Hôpitaux communautaires</term>
<term>Hôpitaux urbains</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Population d'origine africaine</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Ventilation artificielle</term>
<term>Études rétrospectives</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Infection with SARS-CoV-2 (COVID-19) can cause prothrombotic complications. We aim to study the frequency of thrombotic complications and impact of anticoagulation on outcomes in hospitalized patients. We conducted a retrospective chart review of 921 consecutive patients admitted to our hospital with COVID-19. Patients were divided into four groups depending on whether they were on anticoagulation prior to admission, started anticoagulation during the admission, received prophylactic anticoagulation, or did not receive any anticoagulation. At the time of analysis, 325 patients (35.3%) had died, while 544 patients (59%) had been discharged resulting in inpatient mortality of 37.3%. Male sex, age > 65 years, and high D-dimer at admission were associated with higher mortality. Sixteen patients (1.7%) had venous thromboembolism confirmed with imaging, 11 patients had a stroke, and 2 patients developed limb ischemia. Treatment with therapeutic anticoagulation was associated with improved inpatient mortality compared with prophylactic anticoagulation alone (63% vs 86.2%, p < 0.0001) in patients requiring mechanical ventilation. Other outcomes such as rates of liberation from mechanical ventilation and duration of mechanical ventilation were not significantly impacted by the type of anticoagulation.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32808105</PMID>
<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>16</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>29</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-0584</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>99</Volume>
<Issue>10</Issue>
<PubDate><Year>2020</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Annals of hematology</Title>
<ISOAbbreviation>Ann Hematol</ISOAbbreviation>
</Journal>
<ArticleTitle>Thrombotic complications and anticoagulation in COVID-19 pneumonia: a New York City hospital experience.</ArticleTitle>
<Pagination><MedlinePgn>2323-2328</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00277-020-04216-x</ELocationID>
<Abstract><AbstractText>Infection with SARS-CoV-2 (COVID-19) can cause prothrombotic complications. We aim to study the frequency of thrombotic complications and impact of anticoagulation on outcomes in hospitalized patients. We conducted a retrospective chart review of 921 consecutive patients admitted to our hospital with COVID-19. Patients were divided into four groups depending on whether they were on anticoagulation prior to admission, started anticoagulation during the admission, received prophylactic anticoagulation, or did not receive any anticoagulation. At the time of analysis, 325 patients (35.3%) had died, while 544 patients (59%) had been discharged resulting in inpatient mortality of 37.3%. Male sex, age > 65 years, and high D-dimer at admission were associated with higher mortality. Sixteen patients (1.7%) had venous thromboembolism confirmed with imaging, 11 patients had a stroke, and 2 patients developed limb ischemia. Treatment with therapeutic anticoagulation was associated with improved inpatient mortality compared with prophylactic anticoagulation alone (63% vs 86.2%, p < 0.0001) in patients requiring mechanical ventilation. Other outcomes such as rates of liberation from mechanical ventilation and duration of mechanical ventilation were not significantly impacted by the type of anticoagulation.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hanif</LastName>
<ForeName>Ahmad</ForeName>
<Initials>A</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-5358-8862</Identifier>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Hematology & Oncology, BronxCare Hospital Center, Bronx, NY, USA. ahhanif@BronxCare.org.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Khan</LastName>
<ForeName>Sumera</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, BronxCare Hospital Center, Bronx, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mantri</LastName>
<ForeName>Nikhitha</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, BronxCare Hospital Center, Bronx, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hanif</LastName>
<ForeName>Sana</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, BronxCare Hospital Center, Bronx, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Saleh</LastName>
<ForeName>Muhamed</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, BronxCare Hospital Center, Bronx, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alla</LastName>
<ForeName>Yamini</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, BronxCare Hospital Center, Bronx, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chinta</LastName>
<ForeName>Siddharth</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, BronxCare Hospital Center, Bronx, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shrestha</LastName>
<ForeName>Nikee</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, BronxCare Hospital Center, Bronx, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ji</LastName>
<ForeName>Wenyan</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Biostatistics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Attwood</LastName>
<ForeName>Kristopher</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Biostatistics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Adrish</LastName>
<ForeName>Muhammad</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Pulmonary and Critical Care, BronxCare Hospital Center, Bronx, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jain</LastName>
<ForeName>Kevin R</ForeName>
<Initials>KR</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Division of Hematology & Oncology, BronxCare Hospital Center, Bronx, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>17</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Ann Hematol</MedlineTA>
<NlmUniqueID>9107334</NlmUniqueID>
<ISSNLinking>0939-5555</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000925">Anticoagulants</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D044383" MajorTopicYN="N">African Continental Ancestry Group</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000925" MajorTopicYN="N">Anticoagulants</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006470" MajorTopicYN="N">Hemorrhage</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006630" MajorTopicYN="N">Hispanic Americans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006764" MajorTopicYN="N">Hospitals, Community</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006786" MajorTopicYN="N">Hospitals, Urban</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007902" MajorTopicYN="N">Length of Stay</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009519" MajorTopicYN="N" Type="Geographic">New York City</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020521" MajorTopicYN="N">Stroke</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013927" MajorTopicYN="N">Thrombosis</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054556" MajorTopicYN="N">Venous Thromboembolism</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anticoagulation</Keyword>
<Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">Mortality</Keyword>
<Keyword MajorTopicYN="N">Thrombosis</Keyword>
<Keyword MajorTopicYN="N">Venous thromboembolism</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>05</Month>
<Day>27</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>08</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>8</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>9</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>8</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32808105</ArticleId>
<ArticleId IdType="doi">10.1007/s00277-020-04216-x</ArticleId>
<ArticleId IdType="pii">10.1007/s00277-020-04216-x</ArticleId>
<ArticleId IdType="pmc">PMC7430929</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Hanif, Ahmad" sort="Hanif, Ahmad" uniqKey="Hanif A" first="Ahmad" last="Hanif">Ahmad Hanif</name>
</region>
<name sortKey="Adrish, Muhammad" sort="Adrish, Muhammad" uniqKey="Adrish M" first="Muhammad" last="Adrish">Muhammad Adrish</name>
<name sortKey="Alla, Yamini" sort="Alla, Yamini" uniqKey="Alla Y" first="Yamini" last="Alla">Yamini Alla</name>
<name sortKey="Attwood, Kristopher" sort="Attwood, Kristopher" uniqKey="Attwood K" first="Kristopher" last="Attwood">Kristopher Attwood</name>
<name sortKey="Chinta, Siddharth" sort="Chinta, Siddharth" uniqKey="Chinta S" first="Siddharth" last="Chinta">Siddharth Chinta</name>
<name sortKey="Hanif, Sana" sort="Hanif, Sana" uniqKey="Hanif S" first="Sana" last="Hanif">Sana Hanif</name>
<name sortKey="Jain, Kevin R" sort="Jain, Kevin R" uniqKey="Jain K" first="Kevin R" last="Jain">Kevin R. Jain</name>
<name sortKey="Ji, Wenyan" sort="Ji, Wenyan" uniqKey="Ji W" first="Wenyan" last="Ji">Wenyan Ji</name>
<name sortKey="Khan, Sumera" sort="Khan, Sumera" uniqKey="Khan S" first="Sumera" last="Khan">Sumera Khan</name>
<name sortKey="Mantri, Nikhitha" sort="Mantri, Nikhitha" uniqKey="Mantri N" first="Nikhitha" last="Mantri">Nikhitha Mantri</name>
<name sortKey="Saleh, Muhamed" sort="Saleh, Muhamed" uniqKey="Saleh M" first="Muhamed" last="Saleh">Muhamed Saleh</name>
<name sortKey="Shrestha, Nikee" sort="Shrestha, Nikee" uniqKey="Shrestha N" first="Nikee" last="Shrestha">Nikee Shrestha</name>
</country>
</tree>
</affiliations>
</record>

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Thrombotic complications and anticoagulation in COVID-19 pneumonia: a New York City hospital experience.

Thrombotic complications and anticoagulation in COVID-19 pneumonia: a New York City hospital experience.

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